Studies on tableting properties of lactose
نویسندگان
چکیده
منابع مشابه
Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose.
Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on...
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This review provides an insight into mechanical properties that are critical to understanding powder processing for tableting. Various parameters that reflect these basic fundamental properties of powder and their evaluation by different techniques are described. Some recent examples in which these techniques are used in drug substance selection, formulation optimization or scale-up are also pr...
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Understanding the relationship between processing parameters of fluidized bed wet granulation and the characteristics of intermediate and final products is crucial in the pharmaceutical processes. This research examined a fluidized bed wet granulation process containing a cornstarch solution as binder and lactose particles as powder. The design of experiment (DoE) was performed according to an ...
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Direct tableting has been renewed as a preferable process by simply mixing and compressing powder to save time and cost in comparison with granule tableting. Direct compression tableting as a technique has been successfully applied to numerous drugs on the industrial scale, although the success of any procedure, and resulting mechanical properties of tablets, is strongly affected by the quality...
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ژورنال
عنوان ژورنال: Pharmaceutisch Weekblad
سال: 1985
ISSN: 0031-6911,1573-739X
DOI: 10.1007/bf02307575